Analogy: Imagine your job is to assemble furniture for people, but the furniture comes with all the pieces except the screws to hold everything together, so in order to complete the assembly, you used your own personal supply of screws.
At some point after assembling a certain number of pieces of furniture, you will have eventually run out of your own supply of screws.
When you take painkillers or anti-inflammatory medicine, such as ibuprofen, Tylenol, aspirin, et al. your body has to draw from its own nutrient stores, and after prolonged use will eventually be depleted of those nutrients.
The same is true of almost all medications and medicines
Be careful when taking any medicines, whether they are prescription meds or over-the-counter remedies, whatever you take may be causing a nutrient deficiency that you need to take into account.
As always, consult with your physician before making any changes.